M. Prinz

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

An acute microglial metabolic response controls metabolism and improves memory

The paper identifies an acute microglial metabolic response to high-fat diet that improves metabolism and memory by converting harmful fatty acids into beneficial metabolites.

DNA damage signaling in Drosophila macrophages modulates systemic cytokine levels in response 1 to oxidative stress

This study identifies DNA damage signaling in Drosophila macrophages as a key regulator of cytokine release and oxidative stress response through JNK and unpaired-3.

Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood

This study shows that intestinal macrophages refine the enteric nervous system early in life by pruning synapses and phagocytosing neurons, and maintain neuron survival post-weaning through a TGFβ-driven microglia-like phenotype.

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

This study identifies microenvironmental factors driving transcriptional heterogeneity in glioblastomas through spatial transcriptomics, metabolomics, and proteomics.

Lineage and Spatial Mapping of Glioblastoma-associated Immunity

This study maps immune cell states and interactions in glioblastoma, identifying IL-10-driven T cell exhaustion and myeloid-lymphoid interactions contributing to immunosuppression.

ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma

This study identifies ZBTB18 as a regulator of SREBP gene expression in glioblastoma by modulating CTBP and LSD1 activity, leading to epigenetic repression of fatty acid synthesis.

ISG15 drives immune pathology and respiratory failure during viral infection

This study shows that lack of deISGylation during viral infection leads to immune pathology and respiratory failure, with extracellular ISG15 playing a key role in inflammation and disease severity.

Comparative analysis of CreER transgenic mice for the study of brain macrophages - a case study

The paper compares two CreER transgenic mouse models to assess their utility in studying brain macrophages and highlights considerations for their use.

Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge

This study compares transcriptomes, epigenomes, and responses to challenge between engrafted HSC-derived brain macrophages and host microglia, finding persistent molecular and functional differences.