Succinate mediates inflammation-induced adrenocortical dysfunction
I. Mateska, A. Witt, E. Hagag, A. Sinha, C. Yilmaz, E. Thanou, N. Sun, O. Kolliniati, M. Patschin, H. Abdelmegeed, H. Henneicke, W. Kanczkowski, B. Wielockx, C. Tsatsanis, A. Dahl, , V. I. Alexaki
This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.
bioRxiv · Apr 29, 2022Immunology