A. Witt

Fibroblast Stromal Support Model for Predicting Human Papillomavirus-Associated Cancer Drug Responses.

This paper develops a fibroblast co-culture model to predict drug responses in HPV+ cancers and shows it better predicts in vivo outcomes than in vitro alone.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

Inhibition of LATS Kinases in Ovarian Cancer Activates Cyclin D1/CDK4 and Decreases DYRK1A Activity

This study shows that inhibiting LATS kinases in ovarian cancer cells activates cyclin D1/CDK4 and reduces DYRK1A activity, promoting tumor growth.

Intercellular Mitochondrial Transfer as a Rescue Mechanism in Response to Protein Import Failure

This study shows that mammalian cells can rescue mitochondrial protein import failure by transferring healthy mitochondria between cells via tunneling nanotubes.

Succinate mediates inflammation-induced adrenocortical dysfunction

This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.

Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production

This study identifies obesity-induced lipidomic changes in the adrenal gland, showing that the FADS2-arachidonic acid pathway regulates adrenocortical hormone production.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.