N. Sun

Grand Biological Universe: Genome space geometry unravels looking for a single metric is likely to be futile in evolution

This study explores genome space geometry across seven kingdoms, showing that a single metric cannot accurately measure differences between biological universes due to space-time distortion.

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

This study investigates the role of mouse mammary tumor virus (MMTV) in colitis and dysbiosis in IL-10-/- mice, finding that MMTV contributes to disease severity and that antiretroviral therapy reduces MMTV load and improves symptoms.

A novel non-invasive biomarker based on oral microbiome dysbiosis for detection of Community-Acquired Pneumonia

This study identifies oral microbiome dysbiosis as a non-invasive biomarker for detecting community-acquired pneumonia.

Multiple omic investigations of freeze tolerance adaptation in the aquatic ectothermic vertebrate, the Amur sleeper

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

Succinate mediates inflammation-induced adrenocortical dysfunction

This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Molecular signature of RV cardiac remodeling associated with Polymerase Gamma mutation

This study characterizes cardiac remodeling in POLG mutant mice, identifying sex-specific differences and RNA-seq-driven insights into inflammation, fibrosis, and heart failure pathways.

Magnetic Temporal Interference for Noninvasive Focal Brain Stimulation

This paper introduces magnetic temporal interference as a method to noninvasively stimulate specific brain regions in rodents, showing increased neuronal activation in targeted areas compared to non-targeted regions.

Deep Learning-powered Bessel-beam Multi-parametric Photoacoustic Microscopy

This paper develops a Bessel-beam multi-parametric photoacoustic microscopy system enhanced by deep learning to improve quantitative imaging of hemoglobin concentration, oxygen saturation, and cerebral blood flow in live mouse brains.

The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling

This study shows Parkin promotes AKT degradation during mitophagy, while USP30 protects AKT, influencing cell apoptosis and USP30's broader physiological roles.

Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma

This study identifies functional metabolic differences between PDAC subtypes and shows that non-invasive HP-MRS can detect glycolytic tumor metabolism.

Regulation of DNA damage response by trimeric G-protein Signaling

This paper shows that GIV/Girdin modulates DNA damage response by suppressing HR and promoting NHEJ through BRCA1 sequestration and Akt pathway activation.

Network-based integration of epigenetic landscapes unveils molecular programs underlying human T follicular helper cell differentiation

The paper integrates epigenomic data with a protein interactome to identify molecular programs driving human Tfh cell differentiation and links these to immune signaling in severe COVID-19.

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

This study identifies microenvironmental factors driving transcriptional heterogeneity in glioblastomas through spatial transcriptomics, metabolomics, and proteomics.

Magnetic Temporal Interference For Noninvasive, High-resolution, and Localized Deep Brain Stimulation: Concept Validation

The paper validates a concept using magnetic temporal interference to achieve noninvasive, high-resolution, and localized deep brain stimulation by exploiting low-frequency envelope stimulation from interfering high-frequency fields.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

Ultra-compact Dual-band Smart NEMS Magnetoelectric Antennas for Simultaneous Wireless Energy Harvesting and Magnetic Field Sensing

This paper introduces an ultra-compact dual-band smart NEMS magnetoelectric antenna for wireless energy harvesting and magnetic field sensing in implantable medical devices.

B1 and B2 B cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

The paper identifies distinct CpG modification states in B1 and B2 B cells at DNMT3A-maintained enhancers, showing differential methylation dynamics during development.

Validation of a CRISPR/cas9-based technology platform for examining specific immune gene functions in an experimental murine model of IBD

The paper validates a CRISPR/Cas9 platform for studying immune gene functions in a murine IBD model, demonstrating its utility for in vivo validation of therapeutic targets.

VHL Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens

The paper uses CRISPR-Cas9 screens in isogenic ccRCC cell lines to identify synthetic lethal partners of VHL, revealing new therapeutic targets for renal cell carcinoma.

Circadian gene Clock regulates mitochondrial morphology and functions by posttranscriptional way

This study shows that the circadian gene Clock regulates mitochondrial morphology and function through posttranscriptional control of Drp1, leading to metabolic disorders and NAFLD.

Akt/PKB enhances non-canonical Wnt signals by compartmentalizing β-Catenin

This study shows that Akt/PKB enhances non-canonical Wnt signals by phosphorylating Daple, which compartmentalizes β-catenin to cell-cell contact sites, suppressing colony growth.

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.