Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans
F. G. S. Silao, M. Ward, K. Ryman, A. Wallstrom, B. Brindefalk, K. Udekwu, P. O. Ljungdahl
This study shows that mitochondrial proline metabolism via PUT1 and PUT2 enhances ATP production, activates the Ras1/cAMP/PKA pathway, and promotes filamentation in C. albicans, contributing to virulence.
bioRxiv · Jul 23, 2018Microbiology