Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant
X. Bao, M. C. Koorengevel, M. J. A. Groot Koerkamp, A. Homavar, A. Weijn, S. Crielaard, M. F. Renne, W. J. C. Geerts, M. A. Surma, M. Mari, F. C. P. Holstege, C. Klose, A. I. P. M. de Kroon
This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.
bioRxiv · Feb 8, 2021Biochemistry