C. Klose

Cholesteryl hemiazelate Identified in Cardiovascular Disease Patients Causes in vitro and in vivo Inflammation

The paper identifies cholesteryl hemiazelate (ChA) as an oxidized lipid that induces inflammation in vitro and in vivo, contributing to atherosclerosis.

Remodeling of yeast vacuole membrane lipidomes from the log (1-phase) to stationary stage (2-phases)

This paper investigates lipid composition changes in yeast vacuole membranes during growth to quiescence, finding increased phosphatidylcholine with higher melting temperatures.

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

The paper introduces a method to isolate organellar membranes from yeast and uses it to study lipid composition and stress responses in the endoplasmic reticulum and vacuolar membranes.

Phytochromes mediate germination inhibition under red, far-red, and white light in Aethionema arabicum

The study identifies a phytochrome chromophore biosynthesis mutant in Aethionema arabicum, showing phytochromes mediate light inhibition of seed germination and influence plant morphology.

Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis

This study shows that progranulin deficiency reduces bis(monoacylglycero)phosphate levels, leading to gangliosidosis and neurodegeneration.

Flexibility of a mammalian lipidome - insights from mouse lipidomics

The paper investigates how diet, sex, and genotype affect the mouse lipidome across tissues, organs, and bodily fluids, providing baseline lipidomic data and insights into organ-specific flexibility.

Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

This study identifies cholesteryl hemiazelate as a cause of lysosome dysfunction and exocytosis in macrophages, contributing to atherosclerosis.

Phytochromes measure photoperiod in Brachypodium

This study shows that phytochrome C (phyC) in Brachypodium distachyon acts as a molecular timer that communicates night length information to the circadian clock protein ELF3, regulating photoperiodic responses.

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.

PWO1 interacts with PcG proteins and histones to regulate Arabidopsis flowering and development.