PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation
S. K. See, M. Chen, S. Bax, R. Tian, A. Woerman, E. Tse, I. E. Johnson, C. Nowotny, E. N. Munoz, J. Sengstack, D. R. Southworth, J. E. Gestwicki, M. D. Leonetti, M. Kampmann
The paper identifies PIKfyve inhibition as a strategy to block α-synuclein fibril escape from lysosomes, reducing aggregation spread in a human cell model.
bioRxiv · Jan 21, 2021 · PreprintCell Biology