A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells
M. Y. Mboge, Z. Chen, D. Khokhar, A. Wolff, L. Ai, C. D. Heldermon, M. Boxdag, F. Carta, C. T. Supuran, K. D. Brown, R. McKenna, C. J. Frost, S. C. Frost
This study shows that carbonic anhydrase IX (CA IX) contributes to pH regulation and glycolytic phenotype in breast cancer cells through a non-catalytic function, independent of its enzymatic activity.
bioRxiv · Mar 5, 2019Cancer Biology