Author

L. Ai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. Zhang· 2 shared Y. Li· 2 shared A. Sitikov· 1 shared A. Wolff· 1 shared B. Lv· 1 shared C. D. Heldermon· 1 shared C. J. Frost· 1 shared C. Ji· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

H. Zhang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction

K. Ullah, L. Ai, Y. Li, L. Liu, Q. Zhang, K. Pan, Z. Humayun, L. Piao, A. Sitikov, Q. Su, Q. Zhao, W. W. Sharp, Y. Fang, D. Wu, J. K. Liao, R. Wu

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

bioRxiv · Mar 12, 2023 · PreprintCell Biology

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

L. Ai, Y. Li, L. Zhou, H. Zhang, W. Yao, J. Han, J. Wu, R. Wang, W. Wang, P. Xu, Z. Li, C. Wei, H. Chen, J. Liang, M. Guo, , Y. Hu

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

bioRxiv · Feb 10, 2022Immunology

Association of CD44-/CD24- Breast Cancer Cells with Late Stage Tumor Recurrence

C. Liu, X. Qiao, Y. Zhang, L. Sun, Q. Ma, J. Yang, L. Ai, J. Xue, G. Chen, H. Zhang, C. Ji, X. Gu, H. Lei, Y. Yang

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

bioRxiv · Dec 7, 2020 · PreprintPhysiology

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

M. Y. Mboge, Z. Chen, D. Khokhar, A. Wolff, L. Ai, C. D. Heldermon, M. Boxdag, F. Carta, C. T. Supuran, K. D. Brown, R. McKenna, C. J. Frost, S. C. Frost

This study shows that carbonic anhydrase IX (CA IX) contributes to pH regulation and glycolytic phenotype in breast cancer cells through a non-catalytic function, independent of its enzymatic activity.

bioRxiv · Mar 5, 2019Cancer Biology