Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2
C. Planchais, A. Reyes-Ruiz, R. Lacombe, A. Zarantonello, M. Lecerf, M. Revel, L. T. Roumenina, B. P. Atanasov, H. Mouquet, J. D. Dimitrov
The paper investigates how the SARS-CoV-2 spike protein's interaction with ACE2 evolved, revealing changes in binding dynamics and physicochemical forces across variants.
bioRxiv · Jun 11, 2022Biochemistry