J. D. Dimitrov

This study shows that bat antibodies change their antigen-binding properties with temperature, linking metabolic state to immune diversity and anti-inflammatory function.

The paper identifies sequence patterns in antibody variable regions that determine polyreactivity across different B cell subpopulations and shows distinct patterns for each subpopulation.

This study identifies Dlk2 as a regulator of Numb/Notch pathway in zebrafish neurogenesis and human cancer, showing its role in modulating Numb phosphorylation and Notch signaling.

The paper investigates how the SARS-CoV-2 spike protein's interaction with ACE2 evolved, revealing changes in binding dynamics and physicochemical forces across variants.

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

The paper shows that human IgA can acquire polyreactivity when exposed to acidic pH, heme, or ferrous ions, increasing reactivity to bacterial and viral antigens.

The paper shows that clinical-stage antibodies interacting with heme have specific sequence traits and functional qualities that predict therapeutic failure.

This paper introduces an immunosorbent assay for identifying heme-binding proteins and quantifying their interactions with minimal protein amounts.