M. Lecerf

Temperature sensitivity of bat antibodies links metabolic state with antigen-recognition diversity

This study shows that bat antibodies change their antigen-binding properties with temperature, linking metabolic state to immune diversity and anti-inflammatory function.

Polyreactivity of antibodies from different B cell subpopulations is determined by distinct sequence patterns of variable region

The paper identifies sequence patterns in antibody variable regions that determine polyreactivity across different B cell subpopulations and shows distinct patterns for each subpopulation.

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

The paper investigates how the SARS-CoV-2 spike protein's interaction with ACE2 evolved, revealing changes in binding dynamics and physicochemical forces across variants.

Induced antigen-binding polyreactivity in human serum IgA

The paper shows that human IgA can acquire polyreactivity when exposed to acidic pH, heme, or ferrous ions, increasing reactivity to bacterial and viral antigens.

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

The paper shows that clinical-stage antibodies interacting with heme have specific sequence traits and functional qualities that predict therapeutic failure.

Method for identification of heme-binding proteins and quantification of their interactions

This paper introduces an immunosorbent assay for identifying heme-binding proteins and quantifying their interactions with minimal protein amounts.