Absence of muricholic acid due to Cyp2c-deficiency protects against high fat diet-induced obesity in male mice but promotes liver damage
A.-B. Oteng, S. Higuchi, A. S. Banks, R. A. Haeusler
This study shows that Cyp2c-deficient mice are protected from obesity on a high fat diet but experience increased liver damage, suggesting MCAs may protect against liver injury rather than obesity.
bioRxiv · May 10, 2021Physiology