S. Higuchi

The python-derived 16α-hydroxylated bile acid, pythocholic acid decreases food intake and increases jejunal fatty acid ethanolamides in mice.

This paper isolates pythocholic acid from ball pythons and shows it reduces food intake and increases jejunal fatty acid ethanolamides in mice, unlike deoxycholic acid.

Improving the Safety of Cultured Meat Using Basal Medium Prepared using Food Ingredients

This study develops a food-grade medium for cultured meat production, showing it supports cell growth and differentiation similarly to standard medium.

Absence of muricholic acid due to Cyp2c-deficiency protects against high fat diet-induced obesity in male mice but promotes liver damage

This study shows that Cyp2c-deficient mice are protected from obesity on a high fat diet but experience increased liver damage, suggesting MCAs may protect against liver injury rather than obesity.

Fat Mass Regain in Middle-Aged Mice after Sleeve Gastrectomy is divergent from plasma leptin levels

This study shows that middle-aged mice undergoing sleeve gastrectomy experience fat mass regain in the second month post-surgery, while plasma leptin levels remain low.

Sleeve gastrectomy promotes sustained weight loss while increasing heat production in middle aged, obese female mice

This study shows that sleeve gastrectomy in middle-aged obese female mice leads to sustained weight loss and improved glucose tolerance, associated with increased brown adipose tissue metabolism.

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

This study shows that bile acid composition, particularly 12-hydroxylated bile acids, regulates the manganese transporter Slc30a10 in the intestine via lithocholic acid signaling through the vitamin D receptor.