Author

A.-J. Roura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

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Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Kaminska· 4 shared B. Wojtas· 4 shared M. J. Dabrowski· 3 shared B. Gielniewski· 2 shared K. Poleszak· 2 shared K. Stepniak· 2 shared P. Szadkowska· 2 shared A. Ellert-Miklaszewska· 1 shared

Activity by Year

2020-2022 · peak 2/yr

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10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

B. Kaminska

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4 papers

Recent·Most cited

Comprehensive analysis of the transcription factor REST regulatory networks in IDH-mutant and IDH-wild type glioma

M. Perycz, M. J. Dabrowski, M. Jardanowska, A.-J. Roura, B. Gielniewski, K. Stepniak, M. Draminski, B. Kaminska, B. Wojtas

This study identifies differences in REST regulatory networks between IDH-mutant and IDH-wild type gliomas, highlighting distinct gene expression control mechanisms.

bioRxiv · Jul 28, 2022 · PreprintCancer Biology

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

A.-J. Roura, P. Szadkowska, K. Poleszak, M. J. Dabrowski, A. Ellert-Miklaszewska, K. Wojnicki, I. A. Ciechomska, K. Stepniak, B. Kaminska, B. Wojtas

The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.

bioRxiv · Jul 18, 2022Cancer Biology

Epigenetic regulation of differentially expressed genes between various glioma types

I. E. Grabowicz, B. Wilczynski, B. Kaminska, A.-J. Roura, B. Wojtas, M. J. Dabrowski

The paper integrates epigenetic and transcriptomic data to identify gene regulatory networks and chromatin organization differences between low and high grade gliomas.

bioRxiv · Aug 29, 2020 · PreprintCancer Biology

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

B. Gielniewski, K. Poleszak, A.-J. Roura, P. Szadkowska, S. K. Krol, R. Guzik, P. Wiechecka, M. Maleszewska, B. Kaza, A. Marchel, T. Czernicki, A. Koziarski, G. Zielinski, A. Styk, M. Kawecki, , B. Kaminska

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

bioRxiv · Jun 17, 2020 · PreprintCancer Biology