Cancer BiologybioRxivPreprint
The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma
B. Gielniewski, K. Poleszak, A.-J. Roura…·B. Kaminska
The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.
DOI 10.1101/2020.06.17.158477