Author

A.-L. Soulet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:cryo-EM· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Polard· 5 shared C. H. G. JOHNSTON· 3 shared D. De Lemos· 3 shared M. Prudhomme· 2 shared R. Fronzes· 2 shared E. Le Cam· 1 shared E. Margeat· 1 shared E. Vernhes· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersMicrobiology

P. Polard

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5 papers

Recent·Most cited

Structural basis for activation and mechanism of the bacterial hexameric motors RadA and ComM in DNA branch migration during homologous recombination

L. T. Rosa, E. Vernhes, a.-L. Soulet, P. Polard, R. Fronzes

This study presents cryoEM structures of RadA and ComM, revealing their mechanisms of ATP hydrolysis and DNA branch migration during homologous recombination.

bioRxiv · Feb 15, 2024 · PreprintMicrobiology

Pneumococcal competence, a populational health sensor driving multilevel heterogeneity in response to antibiotics.

M. Prudhomme, C. H. G. JOHNSTON, A.-L. Soulet, D. De Lemos, N. Campo, P. Polard

This study reveals a populational QS mechanism in Streptococcus pneumoniae that drives antibiotic response heterogeneity through competence-induced bet-hedging.

bioRxiv · Nov 17, 2023 · PreprintMicrobiology

The RecA-directed recombination pathway of natural transformation initiates at chromosomal replication forks in Streptococcus pneumoniae.

C. H. G. JOHNSTON, R. HOPE, A.-L. SOULET, M. DEWAILLY, D. DE LEMOS, P. POLARD

This study shows that RecA and DprA accumulate at replication forks during natural transformation in Streptococcus pneumoniae, linking HR with replication.

bioRxiv · Aug 4, 2022Microbiology

Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae.

M. Hertzog, T. N. Perry, P. Dupaigne, S. Serres, V. Morales, A.-L. Soulet, J. Bell, E. Margeat, S. C. Kowalczykowski, E. Le Cam, R. Fronzes, P. Polard

This study characterizes the ATP-dependent assembly mechanism and cryoEM structure of RecA nucleofilaments from Streptococcus pneumoniae, revealing differences in ssDNA binding and HR activity compared to Escherichia coli.

bioRxiv · Jul 28, 2022 · PreprintMicrobiology

The alternative sigma factor σX mediates competence shut-off at the cell pole in Streptococcus pneumoniae.

C. H. G. Johnston, A.-L. Soulet, M. Berge, M. Prudhomme, D. De Lemos, P. Polard

This study identifies σX as a key regulator that spatially coordinates competence shut-off by anchoring DprA at the cell pole in Streptococcus pneumoniae.

bioRxiv · Jun 12, 2020Microbiology