A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles
A. Chen, A.-M. Lupan, R. T. Quek, S. G. Stanciu, M. Asaftei, G. A. Stanciu, K. Hardy, T. Magalhaes, P. A. Silver, T. Mitchison, A. Salic
This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.
bioRxiv · Jun 18, 2024 · PreprintBiochemistry