T. Mitchison

A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles

This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.

Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline

The paper quantifies how SARS-CoV-2 ORF6 inhibits nuclear transport and finds it is more potent than SARS-CoV-1 ORF6 due to differences in its C-terminal region.

Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion

The paper measures microtubule depolymerization rates in Xenopus egg extract asters and finds higher rates in the interior compared to the periphery, suggesting regulation by MAP depletion.

Disassembly of actin and keratin networks by Aurora B kinase at the midplane of cleaving Xenopus laevis eggs

The paper investigates how Aurora B kinase disassembles actin and keratin networks at the midplane of cleaving Xenopus laevis eggs, facilitating cytokinesis.