Author

P. A. Silver

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 3 Biochemistry· 1 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. B. Hsu· 2 shared J. C. Way· 2 shared L. Lyon· 2 shared A. A. Verdegaal· 1 shared A. R. Graveline· 1 shared A. S. Khalil· 1 shared A. Sonti· 1 shared A. Vernet· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

B. B. Hsu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An Fc-SPINK1 fusion protein inhibits pancreatic inflammation in a mouse model

Jeffrey C. Way, Daniel Heid, M. Theiß, Simon Flyvbjerg Nørrelykke, Lucas Barck, L. Burger, J. A. Bredl, Thorge Dobbertin, P. Höflich, Tobias Stadelmann, Dominik Niopek, Katherine Redfield Chan, R. Sivaraman, A. R. Graveline, A. Vernet, , P. A. Silver

This paper develops an Fc-SPINK1 fusion protein that reduces pancreatic inflammation in mice by extending its half-life and inhibiting trypsin activity.

bioRxiv · Feb 21, 2025 · PreprintPharmacology & Toxicology

High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfection

S. Lim, R. R. Yocum, P. A. Silver, J. C. Way

This study compares genomic integration rates of different DNA forms in mammalian cells, finding that end-modified linear DNAs still integrate at high rates.

bioRxiv · Dec 19, 2022 · PreprintBioengineering

In situ reprogramming of gut bacteria by oral delivery

B. B. Hsu, I. N. Plant, L. Lyon, F. M. Anastassacos, J. C. Way, P. A. Silver

This study demonstrates the oral delivery of an engineered phage to reprogram gut bacteria in situ by targeting gene expression without disrupting the microbiota.

bioRxiv · Apr 15, 2020Bioengineering

Forensic microbial system for high-resolution object provenance

J. Qian, Z.-x. Lu, C. P. Mancuso, H.-Y. Jhuang, R. d. C. Barajas-Ornelas, S. Boswell, F. H. Ramirez-Guadiana, V. Jones, A. Sonti, K. Sedlack, L. Artzi, G. Jung, M. Arammash, M. Melfi, L. Lyon, , M. Springer

This paper develops a synthetic microbial spore system for high-resolution object provenance tracking with rapid decoding and biocontainment.

bioRxiv · Mar 14, 2020 · PreprintBioengineering

Structure and function of a 9.6 megadalton bacterial iron storage compartment

T. W. Giessen, B. J. Orlando, A. A. Verdegaal, M. G. Chambers, J. Gardener, D. C. Bell, G. Birrane, M. Liao, P. A. Silver

This study characterizes a bacterial iron storage compartment using structural methods, revealing its large iron storage capacity and functional mechanism.

bioRxiv · Jan 3, 2019 · PreprintBiochemistry

Bacteriophages dynamically modulate the gut microbiota and metabolome

B. B. Hsu, T. E. Gibson, V. Yeliseyev, Q. Liu, L. Bry, P. A. Silver, G. K. Gerber

This study shows that bacteriophages affect gut bacteria and metabolites in mice, with cascading effects on the microbiome and implications for phage therapy.

bioRxiv · Oct 26, 2018Microbiology

Super-resolution microscopy of the β-carboxysome reveals a homogenous matrix

M. J. Niederhuber, T. J. Lambert, C. Yapp, P. A. Silver, J. K. Polka

The paper uses super-resolution microscopy to study CcmM isoform localization in carboxysomes, finding both isoforms colocalize, revising the internal arrangement model.

bioRxiv · Jan 29, 2017Cell Biology