BioengineeringScientific ReportsPeer-reviewed
Oncogene-Mechanics Axis: KRAS G12C Confers Agility Enabling Malignant Mechano-responses to Peristalsis in Colorectal Cancer
Astha Lamichhane, Vsevolod D. Cheburkanov, Mykyta Kizilov…·Shreya Artha Raghavan
This study shows that KRAS G12C mutations in colorectal cancer cells enhance mechanical agility, enabling them to respond to peristalsis by enriching LGR5+ cancer stem cells, which promotes malignant progression.
DOI 10.1038/s41598-026-68015-6