GenomicsbioRxivPreprint
Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor
Zoe L. Grant, Shuzhen Kuang, Shu Zhang…·Benoit G. Bruneau
This study shows that reduced TBX5 dosage affects 3D chromatin organization in human cardiomyocytes, with cell-to-cell variation and partial protection by CTCF co-occupancy.