GenomicsbioRxivPreprint
A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Ross M. Giglio, Nicholas Y. Hou, Lingting Shi…·Jose Ricardo McFaline-Figueroa
This study uses SCHEMATIC to analyze the molecular response of glioblastoma to EGFR inhibitors, identifying chemotype-specific programs and showing that combined EGFR/PI3K inhibition reduces adaptive transcription.
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