Author

Albert Ruzo

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 1

Frequent Co-Authors

Ali H. BrivanlouiD· 4 shared Anna YoneyiD· 3 shared Eric D. SiggiaiD· 3 shared Fred EtociD· 3 shared Iain MartyniD· 3 shared Jakob Johannes MetzgeriD· 3 shared Shu LiiD· 2 shared Anastasiia NemashkaloiD· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersDevelopmental Biology

Ali H. BrivanlouORCID

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5 papers

Recent·Most cited

Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects.

Szilvia Galgoczi, Albert Ruzo, Christian Markopoulos, Anna Yoney, Tien Phan-Everson, Shu Li, Tomomi Haremaki, Jakob Johannes Metzger, Fred Etoc, Ali H. Brivanlou

This study shows that HTT-CAG expansion in human gastruloids causes ectodermal compartment reduction and altered TGFβ signaling due to polarity defects, indicating early developmental HD effects.

Development · Oct 1, 2021Peer-reviewedDevelopmental Biology

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

Anna Yoney, Fred Etoc, Albert Ruzo, Jakob Johannes Metzger, Iain Martyn, Shu Li, Christoph Kirst, Thomas Carroll, Eric D. Siggia, Ali H. Brivanlou

The paper shows that WNT signaling memory enables ACTIVIN to act as a morphogen in human gastruloids by allowing graded responses to ACTIVIN without altering SMAD2 dynamics.

eLife · Oct 12, 2018Peer-reviewedDevelopmental Biology

Molecular mechanism of symmetry breaking in a 3D model of a human epiblast

Mijo Simunovic, Jakob Johannes Metzger, Fred Etoc, Anna Yoney, Albert Ruzo, Iain Martyn, Gist F. Croft, Ali H. Brivanlou, Eric D. Siggia

The paper generates a 3D human epiblast model to study axial symmetry breaking, showing BMP4 induces symmetry breaking through WNT3 and DKK1.

bioRxiv · May 29, 2018 · PreprintDevelopmental Biology

Self-organization of a functional human organizer by combined WNT and NODAL signalling

Iain Martyn, Tatiane Yumi Nakamura Kanno, Albert Ruzo, Eric D. Siggia, Ali H. Brivanlou

The paper shows that WNT and ACTIVIN signals can induce a functional human organizer in hESCs, characterized by PS formation and EMT markers, and demonstrate its ability to contribute to a secondary axis in chick embryos.

Nature · May 18, 2018Peer-reviewedDevelopmental Biology

Morphogen And Community Effects Determine Cell Fates In Response To BMP4 Signaling In Human Embryonic Stem Cells

Anastasiia Nemashkalo, Albert Ruzo, Idse Heemskerk, Aryeh Warmflash

The paper shows that BMP4 signaling in hESCs leads to single cell fates above a threshold in colonies, while requiring secondary signals and specific densities in standard conditions, with community effects enhancing response to external signals.

Development · Jan 1, 2017Peer-reviewedDevelopmental Biology