Anna Yoney

The paper identifies EOMES as a key mediator of WNT priming in human embryonic stem cells, enabling subsequent Activin-induced mesendodermal differentiation.

This study shows that HTT-CAG expansion in human gastruloids causes ectodermal compartment reduction and altered TGFβ signaling due to polarity defects, indicating early developmental HD effects.

The paper shows that NOGGIN and BMP4 are secreted into opposite extracellular spaces in human epiblasts, with NOGGIN inhibiting BMP4 through apical-to-basal transcytosis.

The paper shows that WNT signaling memory enables ACTIVIN to act as a morphogen in human gastruloids by allowing graded responses to ACTIVIN without altering SMAD2 dynamics.

The paper generates a 3D human epiblast model to study axial symmetry breaking, showing BMP4 induces symmetry breaking through WNT3 and DKK1.