Cancer BiologybioRxivPreprint
ESCRT-III accumulates in micronuclei with ruptured nuclear envelopes
Jessica Willan, Alexa Cleasby, Neftali Flores-Rodriguez…·Barbara Ciani
This study shows ESCRT-III and CHMP7 protect against genomic instability in micronuclei by repairing nuclear envelopes but also generate cytosolic DNA that promotes inflammation in cancer cells.
DOI 10.1101/476630