Glucose derived redox equivalents preserve PKA activity and glucagon secretion during hypoglycaemia
Alexander Frueh, Georgios Katzilieris‐Petras, Caroline L. Pedersen, Maia H. Ekstrand, Ganga Deshar, Renata Ialchina, Hayden Paige, Dorthe Nielsen, Daniel Bjørklund Andersen, Jens Juul Holst, Peter Spegel, Per Pedersen, Jakob Grunnet Knudsen
This study shows that glucose metabolism via the pentose phosphate pathway maintains PKA activity and glucagon secretion during hypoglycaemia by elevating cytosolic redox potential.
bioRxiv · Aug 20, 2026 · PreprintPhysiology