Jens Juul Holst

This study shows that glucose metabolism via the pentose phosphate pathway maintains PKA activity and glucagon secretion during hypoglycaemia by elevating cytosolic redox potential.

This study shows that secretin receptor knockout mice have impaired renal base excretion and increased base retention during prolonged base-loading.

The study shows that enteral OCA prevents cholestasis and intestinal atrophy in neonatal pigs by enhancing bile acid and sterol transport through FXR target genes, with additional intestinal growth benefits.

This paper shows that long-term cytokine exposure impairs alpha-cell glucagon secretion in human islet microtissues, which is partially restored by dual incretin receptor agonists.

This study shows that physical activity enhances gut adaptations, hormone sensitivity, and appetite regulation, aiding in body weight maintenance.

This study shows that inhibiting DPP-4 and NEP in mice improves the detection of intact GLP-1 using commercial ELISA kits, but may affect metabolic outcomes.