Alexandra Lovatt

Connexin50 hemichannels are opened by CO2: implications for lens physiology

This study shows that CO2 opens Cx50 hemichannels in lens cells, allowing lactate and glutamate passage, and that this process is regulated by specific residues and involves Ca2+ influx.

The mechanisms of permselectivity of connexin hemichannels to small molecules

This study investigates permselectivity of connexin hemichannels for small molecules, finding that selectivity varies among connexins and is influenced by factors beyond molecular size.

CO2-sensitive Cx26 hemichannels in dorsal raphe-ventral tegmental area pathway mediate hypercapnic arousal

This study identifies Cx26 hemichannels as a CO2 sensor in serotonergic neurons that mediates hypercapnic arousal by enabling serotonin release.