CO2-sensitive Cx26 hemichannels in dorsal raphe-ventral tegmental area pathway mediate hypercapnic arousal
Lumei Huang, Jack Butler, Alexandra Lovatt, Amol Bhandare, Julien Pelletier, Julia Baran, Emily Hill, Nicholas Dale, Mark J. Wall
This study identifies Cx26 hemichannels as a CO2 sensor in serotonergic neurons that mediates hypercapnic arousal by enabling serotonin release.
bioRxiv · Apr 14, 2025 · PreprintNeuroscience