Pharmacology & ToxicologyACS Chemical BiologyPeer-reviewed
Rational development of a small-molecule activator of CK1γ2 that decreases C99 and beta-amyloid levels
Victor Bustos, Yashoda Krishna Sunkari, Anjana Sinha…·Subhash C. Sinha
This study identifies CK1γ2 as a therapeutic target for Alzheimer's disease by showing its activation reduces C99 and beta-amyloid levels through increased PS1-Ser367 phosphorylation.
3 citations