The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a (Hif1a) during postnatal development
Steph S. Steltzer, Nicole Migotsky, T. Phillips, Syeda N. Lamia, Bachir A. Abeid, K P Lee, Seung-Ho Bae, Connor C. Leek, Sydney Grossman, Moaid Shaik, Allison Risha, Kaitlyn Frey, Claudia Loebel, Jun Hee Lee, Yatrik Madhukar Shah, , Megan Leigh Killian
This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.
Development · Jun 22, 2026Peer-reviewedDevelopmental Biology