Yatrik Madhukar Shah

This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.

This paper engineers tumor-homing bacteria to display immune checkpoint-blocking nanobodies, showing enhanced tumor suppression in mouse models compared to traditional antibody therapies.

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

This study identifies a metabolic vulnerability in colorectal cancer where combining HIF-2 inhibition with cholesterol biosynthesis inhibition using statins enhances ferroptosis, offering a new therapeutic strategy.

This study uses intraoperative arteriovenous sampling to measure tumor metabolism in NSCLC patients, revealing distinct metabolic profiles between tumor and normal lung tissue.

This study develops a genetic, colon-specific mouse model of colorectal cancer driven by K8 and Apc loss, showing increased tumorigenesis and reduced K8 expression in human patients.

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.

This study shows that myoglobin leaks into the serum of anemic mice due to increased sGC activation and expression, which is linked to iron deficiency anemia.

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

This study shows hydrogen sulfide increases intracellular oxygen and destabilizes HIF-1, altering hypoxia sensing and potentially contributing to O2 toxicity diseases.

This study shows glucose metabolism sustains STAT3 activation in colorectal cancer through glycosylated paracrine factors, identifying a potential therapeutic target.

This study investigates the role of labile iron pool dynamics in ferroptosis in colorectal cancer cells and finds that exogenous iron supplementation reduces cell viability without measurable LIP expansion during ferroptosis.

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

This study recharacterizes RSL3 as a broad selenoprotein inhibitor, showing its potential as a therapeutic target for colorectal cancer by inducing ferroptosis.

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

This study shows that chronic hydrogen sulfide exposure alters mitochondrial structure and function in human cells by disrupting cristae and respiratory supercomplexes.

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

This study identifies SLC4A11 as a mediator of ammonia import in hepatocellular carcinoma, showing its role in promoting cancer stemness and tumor growth.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

The paper investigates how enriched versus impoverished housing conditions affect tumorigenesis in a mouse model of colitis-associated colon cancer, finding enriched housing reduces tumor burden.

This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.