Almut Nebel

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

This study identifies rare genetic variants in the IIS/mTOR pathway in long-lived humans and shows they have shared functional effects on lifespan-related traits in mice.

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

Admixture as a source for HLA variation in Neolithic European farming communities

The paper examines HLA variation in Neolithic European farming communities, finding increased HLA diversity due to admixture with western hunter-gatherers, but lower diversity compared to modern populations.

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

The paper traces the origin and spread of the IL23R variant rs11209026-A in Europe, linking its frequency changes to Neolithic agricultural practices and its protective role against inflammatory bowel diseases.

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

This study identifies a new susceptibility locus for severe COVID-19 through a detailed GWAS analysis in European populations, focusing on genetic variants associated with disease severity.

Gene-flow from steppe individuals into Cucuteni-Trypillia associated populations indicates long-standing contacts and gradual admixture

The paper analyzes genome-wide data from Late Cucuteni-Trypillia individuals to show gene-flow from steppe populations into CTC communities, indicating long-standing contacts and gradual admixture.