Stefan Schreiber

Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findings

The paper profiles T cell receptor alpha repertoires in IBD patients across multiple cohorts, identifies disease-associated clonotypes, and validates findings in an independent dataset.

Systematic screening of tryptophan metabolism identifies site- and microbial-specific signatures of tryptophan utilization in experimental colitis

This study identifies microbial-specific Trp metabolism signatures in colitis by analyzing metabolites across multiple compartments in mice treated with DSS and antibiotics.

Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD

This study uses metabolic modeling to uncover host-microbiome metabolic dysregulation in IBD, identifying key pathways and potential therapeutic interventions.

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

The paper traces the origin and spread of the IL23R variant rs11209026-A in Europe, linking its frequency changes to Neolithic agricultural practices and its protective role against inflammatory bowel diseases.

Insights into the genetic epidemiology of Crohn’s and rare diseases in the Ashkenazi Jewish population

The paper analyzes exome sequencing data from Ashkenazi Jews to identify enriched alleles and their association with genetic risk for Crohn’s disease and rare diseases.