Adam Antebi

This study identifies RUBCN variants in neurodevelopmental disorders and shows they cause autophagy overdrive, leading to neurodegeneration.

This study identifies mTOR's role in longevity through a bile-acid-like hormonal mechanism involving DHS-26/DHRS1 in C. elegans and mammals.

This study shows that restoring ribosomal homeostasis by targeting RNAse P/MRP or mitochondrial ribosome extends lifespan in C. elegans by improving proteostasis and ribosome assembly.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

This study identifies vitamin B12 as a suppressor of Verheij syndrome-like defects in a C. elegans PUF60 model by restoring metabolic balance and splicing.

The paper identifies a TFEB-TGFβ signaling axis that regulates diapause and stem cell longevity across species by coordinating nutrient availability with growth signals.

The paper shows that hil-1/H1-0, a nutrient-regulated linker histone, mediates resilience and restoration during fasting-refeeding in C. elegans and human cells.

This study shows that amyloid-beta precursor protein contributes to non-pathological brain aging and learning decline in killifish and humans.

This study shows that knocking out the cGAS/STING pathway in killifish reduces age-related cellular changes and inflammation but does not extend lifespan.

This study links proteotoxic stress from defective autophagy to epileptogenesis in Drosophila and Vici Syndrome patients, suggesting autophagy-stimulating diets as a potential treatment.

The paper identifies a Mitochondria to ER Stress Response (MERSR) that enhances proteostasis by modulating UPRER and PERK-eIF2 signaling in disease models.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

This study identifies the nuclear RNAi pathway as a regulator of DAF-16/FOXO function, affecting longevity and dauer entry in C. elegans through interactions with the mTORC2-AKT axis.

The paper identifies a splicing factor mutation that enhances longevity in C. elegans by causing intron retention and inhibiting mTOR signaling.

The paper identifies the one carbon folate cycle as a shared metabolic mechanism regulating longevity across species.

This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.

The paper uses FUCCI technology to study cell cycle dynamics during diapause entry and exit in annual killifish embryos, revealing coordinated cellular changes during quiescent states.

This paper introduces a Pluronic gel-based burrowing assay to assess neuromuscular health in C. elegans by measuring their ability to navigate a gel environment.