Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
Erzsebet M. Szatmari, Corey Moran, Sarah J. Cohen, Denys Bashtovyy, Amanda Jacob, Wyatt Paul Bunner, Mary Phipps, Joan Cristino Lora, Robert W. Stackman, Ryohei Yasuda
This study shows that deleting ADAP1/CentA1 in Alzheimer's disease mice reduces cognitive impairment and neuropathological features, with transcriptome analysis identifying Bid as a key mediator.
eNeuro · Nov 1, 2025Peer-reviewedNeuroscience