Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations.
Amit Kumawat, Elisa Tavazzani, Giovanni Lentini, Alessandro Trancuccio, Deni Kukavica, Amanda Oldani, Marco Denegri, Silvia Giuliana Priori, Carlo Camilloni
This study investigates how ICA-105574, an HERG activator, shortens cardiac repolarization in severe LQT2 mutations through molecular mechanisms.
Journal of Biomedical Science · Apr 7, 2025Peer-reviewedBiophysics