Cell BiologybioRxivPreprint
Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman…·Kitai Kim
The paper investigates how aging-dependent dysregulation of EXOSC2 affects cellular traits and finds that PPP2R5E, a PP2A phosphatase subunit, is a key target of EXOSC2, with this regulation maintained in stem cells and cancer.
DOI 10.1101/2025.04.04.647279