Genetic & Genomic MedicineCirculationPeer-reviewed
Monogenic and Polygenic Contributions to QTc Prolongation in the Population
Victor D. Nauffal, Valerie N. Morrill, Sean Joseph Jurgens…·for the TOPMed Investigators
This study investigates how rare and common genetic variations contribute to QT interval duration, finding that both monogenic and polygenic factors influence QTc prolongation, with polygenic risk modulating the effect of rare variants.
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