The Legionella effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1
Ana Katic, Enza Vittori, Stefanie Halter, Kevin Steiner, Anna Leoni Swart, Milad Radiom, Francisco Javier García-Rodríguez, Tobias Jaggi, Xiaodan Li, Jason A. Mears, Carmen Buchrieser, Pedro Escoll, Vikram Govind Panse, Hubert Hilbi
This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.
EMBO Reports · Jun 6, 2026Peer-reviewedMicrobiology