NeurosciencebioRxivPreprint
TDP-43 pathology triggers SRRM4-dependent cryptic splicing of G3BP1 in ALS/FTD
Hana Fakim, Asmita Ghosh, Emmanuel Amzallag…·Christine Vande Velde
The paper shows that TDP-43 pathology causes a cryptic exon in G3BP1 to be included in neurons, leading to a protein that disrupts stress granule dynamics in ALS/FTD.
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