Pharmacology & ToxicologybioRxivPreprint
TP53 mutations and drug sensitivity in acute myeloid leukaemia cells with acquired MDM2 inhibitor resistance
Martin Michaelis, Constanze Schneider, Florian Rothweiler…·Jindrich Cinatl
This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.
DOI 10.1101/404475