The novel HP1a interactor Clump/CG30403 safeguards transposon silencing and reproductive resilience in the Drosophila ovary
Kun Wu, Richard Chang, Andrew Garcia, Jian Fang, Jikui Song, Maria Ninova
bioRxiv · Jul 16, 2026 · PreprintMolecular Biology
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Andrew Garcia
AstraZeneca (United States)
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
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2021-2026 · peak 2/yrCo-Author Collaboration Network
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PD-1 blockade enhances T cell activation by reorchestrating CD28 and CTLA4 ligand interactions
Gee Sung Eun, Jonathan Boyd, Vinh Au, Andrew Garcia, Sašo Čemerski, Simon J. Dovedi, Kristen N. Pollizzi, Michael Loran Dustin, Rajat Varma
This study shows PD-1 blockade enhances T cell activation by altering ligand interactions between CD28, CTLA4, and PD-1, leading to stronger CD28-CD80 co-stimulation.
bioRxiv · Apr 15, 2026 · PreprintImmunology
Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice
Gholson J. Lyon, Joseph Longo, Andrew Garcia, Fatima Inusa, Elaine J. Marchi, Daniel Shi, Max Johannes Dörfel, Thomas Arnesen, Rafael Aldabe, Scott K. Lyons, Melissa Nashat, David Bolton
The paper evaluates maternal effect lethality and genetic background effects in Naa10 knockout mice, finding no replication of maternal effect lethality but some embryonic lethality in specific genetic backgrounds.
PLoS ONE · May 7, 2024Peer-reviewedGenetics
Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway
Hyae Yon Kweon, Mi-Ni Lee, Max Johannes Dörfel, Seungwoon Seo, Leah Gottlieb, Thomas Papazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael J. Flory, Jonathan Crain, Alison J. Sebold, Scott K. Lyons, Ahmed Ismail, , Gholson J. Lyon
The paper identifies Naa12 as a compensatory N-terminal acetyltransferase that rescues Naa10 deficiency in mice, revealing its role in amino-terminal acetylation.
eLife · Aug 6, 2021Peer-reviewedDevelopmental Biology