Cell BiologybioRxivPreprint
Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells
Federica Raguseo, Elliot Fellows, Cesira de Chiara…·Simon J. Boulton
The paper identifies a covalent fragment inhibitor of TYMS that selectively kills ATRX-deficient cells through replication stress.
DOI 10.64898/2026.06.10.731339