Author

Andrew Nelson

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adrianna L. BartolomucciiD· 1 shared Akshaya Vijaya AnnapragadaiD· 1 shared Alice C. EastmaniD· 1 shared Alissa C. GossiD· 1 shared Anna GrekaiD· 1 shared Boris J. N. WinterhoffiD· 1 shared Brianna R. Silverman· 1 shared Carolline Rodrigues MenezesiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Adrianna L. BartolomucciORCID

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Author profile →

3 papers

Recent·Most cited

Structural variation in repeat elements is widespread in normal human tissues and in tumorigenesis

Akshaya Vijaya Annapragada, James White, Hope Orjuela, Adrianna L. Bartolomucci, Alice C. Eastman, Shashikant Koul, Kauí Patrício Lebarbenchon, Daniel C. Bruhm, Sarah Short, Keerti Boyapati, Noushin Niknafs, Carter Norton, Vishruth Girish, Nicholas A. Vulpescu, Sofia Velculescu, , Victor E. Velculescu

The paper identifies widespread mosaic structural variants in normal human tissues and tumors, with repeat-mediated variants impacting functional elements and enabling noninvasive tumor monitoring through cell-free DNA.

bioRxiv · Sep 28, 2026 · PreprintGenomics

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies

Magdalena Riedl Khursigara, Alissa C. Goss, Maria Kost‐Alimova, Keith H. Keller, Christine Danielle De Mata, Ranjithmenon Muraleedharan, Edward Ryan Collantes, Matthew Brown, Elizabeth J. Grinkevich, Felichi Mae Arines, John Lin, Patrick Byrne, Silvana Bazúa‐Valenti, Elizabeth Morici, Julie Roignot, , Anna Greka

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

bioRxiv · Jul 13, 2026 · PreprintCell Biology

Structural basis of autoantibody binding in Neuromyelitis Optica

Meghna Gupta, Nitesh Khandelwal, Andrew Nelson, Peter Hwang, Sergei Pourmal, Jeffrey L. Bennett, Robert Michael Stroud

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.

Science Advances · Feb 21, 2025Peer-reviewedImmunology