Nitesh Khandelwal

This study determines the cryo-EM structures of human ABCD3 in apo and substrate-bound states, revealing how substrate binding induces ATPase activity and provides structural insights into its transport mechanism.

The paper determines the cryo-EM structure of Ycf1 bound to oxidized glutathione and identifies a 'flex-pocket' mechanism for substrate binding and specificity.

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.

The paper determines the cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1, revealing key interactions that regulate transport.