Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice
Cheng Cheng, Kan Yang, Xinwei Wu, Yuefang Zhang, Shifang Shan, Aaron D. Gitler, Anirvan Ghosh, Zilong Qiu
This study shows that CREST mutations in mice lead to neuroinflammatory responses and motor defects similar to ALS, revealing a molecular mechanism involving the CREST-BRG1 complex and cytokine expression.
Translational Neurodegeneration · Apr 2, 2019Peer-reviewedNeuroscience