Eliezer Masliah

PRISM-M is a recurrent framework that simulates how neural representations integrate into stable models, showing context-dependent shifts and predictive accuracy in simulations and fMRI data.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

This study identifies cell-type-specific dysregulated cis-regulatory elements and target genes in Parkinson's disease using multi-omic analyses of single-cell transcriptomes and epigenomes.

The paper develops a PLA method to specifically detect endogenous pS129 α-synuclein in tissue with low background and high specificity.

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

This study identifies small molecules that target the intrinsically disordered ensemble of α-synuclein, showing they can inhibit misfolding, restore phagocytosis, and block cellular transmission of α-synuclein.

The paper identifies genetic modifiers of risk and age at onset in GBA-associated Parkinson disease and Lewy body dementia using large case-control datasets and genome-wide association studies.

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.

The paper uses GSEA to analyze gene expression patterns in HIV-infected patients with and without neurocognitive impairments, finding that neuroinflammation and white matter dysfunction precede NCI.